tecovirimat will improve the degree or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Tecovirimat is really a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for adverse effects if coadministered with delicate substrates of those enzymes.fentanyl intranasal and diazepam both of those raise sedation